272 papers
This paper reveals that *Drosophila* germ-band extension employs a two-state remodeling strategy where the anterior tissue behaves as a fluidized state driven by internal myosin fluctuations, while the posterior tissue acts as a solid undergoing crystal-like ordering and plastic flow induced by external stresses, collectively solving the inhomogeneous reshaping challenge of embryogenesis.
This study establishes hormonally responsive bovine oviductal organoids that accurately mimic the native oviduct's phase-specific molecular signatures and functional secretions, thereby enhancing sperm capacitation and offering a sustainable platform for advancing assisted reproduction technologies.
This study demonstrates that in Drosophila fat body, the stress response factor ATF4 interacts with the steroid hormone receptor EcR by competing with Ultraspiracle to drive context-specific transcriptional programs, where EcR is essential for homeostatic gene activation but dispensable for stress-induced signaling during nutrient deprivation.
This study demonstrates that maternal inflammation disrupts placental barrier integrity via a COX2/PGE2/EP3 signaling pathway that compromises pericyte-endothelium coupling and relays inflammatory signals to the fetus, a mechanism conserved in both mice and humans.
This study investigates how varying climatic conditions affect nestling development in the Thorn-tailed Rayadito across two Patagonian populations, revealing that while hatching weights are significantly influenced by local climate variables and clutch size, growth rates and pre-fledging weights remain largely unaffected by these environmental factors.
This study reveals that during neuronal differentiation, the balanced accumulation of Smo and GPR161 in the primary cilium elevates ciliary cAMP levels to suppress canonical Shh signaling and regulate actin dynamics, thereby ensuring proper neuron polarization and preventing the formation of unstable axon-like projections.
This study demonstrates that BMP antagonists are essential for sustaining zebrafish mandibular growth by preventing ectopic chondrocyte hypertrophy and maintaining cartilage organization within the Meckel's cartilage.
By combining comparative developmental analyses with Bayesian modeling, this study reveals that squamate tooth complexity arises from a broad, persistent epithelial signaling field rather than discrete enamel knots, identifying an alternative patterning mechanism that relaxes evolutionary constraints and enables repeated gains and losses of multicuspidity.
This study demonstrates that the Y-linked gene UTY functions redundantly with its homolog UTX in a demethylase-independent manner to maintain human pluripotency by ensuring proper chromatin accessibility and the recruitment of core transcription factors like OCT4 and SOX2.
This study establishes PPARG as a conserved, essential regulator that directs the differentiation of invasive trophoblast cells and the subsequent transformation of the uterine-placental interface in both humans and rats.
This study demonstrates that the mitochondrial citrate carrier SLC25A1 acts as a cell-autonomous regulator in cardiomyocytes, linking mitochondrial citrate export to the coordination of metabolic and structural maturation essential for proper cardiac differentiation and morphogenesis.
EmbryoTempoFormer is a clip-based CNN-Transformer framework that infers interpretable, embryo-level developmental tempo from zebrafish brightfield time-lapse microscopy, enabling statistically robust quantification of how environmental or genetic perturbations alter developmental dynamics rather than merely shifting nominal time.
This study introduces a high-throughput, real-time luminometry assay that enables minute-scale precision in quantifying the thermal scaling and stage-specific variability of Drosophila larval development, revealing a modular yet coordinated temporal architecture that is robust to temperature changes and compatible with genetic perturbations.
This paper presents a detailed description and a practical staging table of the embryonic development of the convict cichlid (*Amatitlania nigrofasciata*) from fertilization to hatching at 26°C, highlighting key temporal milestones such as rapid early cleavage, asymmetric epiboly, and the overlap of somitogenesis with late gastrulation to facilitate future comparative and experimental research.
This study developed a biomimetic 3D ovarian scaffold by integrating solubilized decellularized ovary extracellular matrix into mechanically tuned alginate and gelatin-alginate hydrogels, successfully replicating native tissue properties and enhancing cell viability to advance regenerative medicine and in vitro ovarian modeling.
This study reveals that during *Cladonema* jellyfish tentacle regeneration, ERK signaling selectively drives the proliferation of injury-induced blastema cells while Notch signaling regulates the balance between self-renewal and differentiation in resident homeostatic stem cells, demonstrating a coordinated division of labor between distinct stem cell populations.
This study challenges the prevailing gland-centric model by demonstrating that the uterine luminal epithelium maintains its own distinct progenitor population and undergoes extensive expansion and morphogenesis to independently regenerate the endometrium during menstruation and pregnancy, rather than relying on glandular cells for repair.
This study identifies ARHGEF6 as a conserved regulator essential for forebrain interneuron migration, maturation, and survival, demonstrating that its dysfunction disrupts inhibitory circuit development and contributes to intellectual disability.
This study demonstrates that apical H-spectrin (SMA-1) organizes cortical actin filament bundles in the *C. elegans* epidermis, which is essential for patterning collagen-rich cuticle ridges by preventing excessive matrix delamination.
By mapping stem cell-based axial organoids to stage-matched human embryos, this study reveals that organoids contain neuromesodermal progenitors with a strong neural bias and identifies TGF-beta inhibition as a key regulator of the transition from anterior to posterior progenitors during human axial elongation.